Instituto Oncológico Dr. Rosell

Oncology Institute Dr. Rosell

USP Hospitales

Oncology laboratory and Molecular pathology

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Oncology laboratory

The Laboratory, led by Dr. Rosell and Dr. Tarón, is located within the University Institute USP Dexeus center and covers an area of 500 m2. Its primary mission is to offer personalized treatments according to the genetic characteristics of the disease, ensuring the quality, speed and accuracy of results allowing for therapy to be tailored to each patient. To achieve this, the laboratory is comprised of technical staff, biologists and pathologists who are highly qualified and specialized in pathology and molecular biology.
Laboratorio oncología

We are the first pharmacogenomics laboratory in Spain to receive accreditation from the Entidad Nacional de Acreditación, ENAC, (National Accreditation Body) in the international standard ISO 15189:2007 Medical Laboratories: Particular requirements for quality and competence, for genetic studies in cancer patients via the analysis of specific mutations or the expression of certain genes (see laboratory accreditation nº 750/LE15156).

Each tumor has its own genetic signature. The laboratory offers the possibility of specific molecular diagnosis, with the latest technology in the field of Molecular Biology, such as the determination of changes in the DNA sequence or the expression of critical genes in cancer using highly sensitive techniques such as PCR, real-time PCR and sequencing.

Teamwork between technical staff, biologists and medical oncologists is essential for the smooth running of the Unit, since continuous contact between all personnel allows for optimum screening and validation of the results, always in a clinical setting.

Molecular pathology

The Molecular Pathology team, led by Dr. Santiago Ramón y Cajal, checks the diagnosis and suitability of the material to be examined and provides correct processing of the samples. The team employs advanced techniques, such as amplification of the Her2/neu gene in breast tumors (FISH) or immunohistochemistry for detecting specific tumor markers, and the laboratory is equipped with a laser dissection microscope.
Molecular testing

Molecular analyses involve an evaluation by an expert pathologist who selects the tumor area.

The molecular analyses carried out in the Laboratory are:

FISH HER2/neu: Trastuzumab breast cancer
KRAS mutations codons 12-13: Cetuximab/Panitumumab colorectal cancer, head and neck cancer
BRAF V600E: Cetuximab colorectal cancer
C-Kit mutations exons 9, 11, 13 and 17 and PDGFR exons 12 and 18: Imatinib gastrointestinal stromal tumors (GIST) and melanoma
EGFR mutations exons 18, 19, 20 and 21: Gefinitib/Erlotinib lung cancer
MGMT methylation: Temozolamide glioblastoma multiforme
PIK3CA mutations: (E542K, E545K, H1047R)
Laboratory team

Laboratory Management: Dr. Rafael Rosell and Dr. Miquel Tarón

Head of Laboratory: Susana Benlloch
Jordi Bertrán
Carlota Costa
Ana Giménez
Clara Mayo
Miguel Ángel Molina

Director, Molecular Pathology: Dr. Santiago Ramón y Cajal
Erika Aldeguer
Sonia Rodríguez
Zaira Yeste

 

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